Tottenham is in situation that may not lose points until end of season if they want take 4th place that can secure champions league. Tottenham is on 5th place currently with 62 points and have two points less then Arsenal that is on that 4th place, but Tottenham played one game less then Arsenal. Next game Tottenham will play away against Chelsea and we can say that they are in must win situation here against Southampton. Tottenham is not in great form and have 2-2-1 in last 5 games and it can not maybe be enough for champions league. They must win almost all games til end of season.
Southampton is on 13th place and have 39 points, 7 points more then Wigan that is in relegation zone. So this game is not so important for Southampton. Ramirez and Fox are suspended for Southampton. Tottenham have not big injure problems. So i think that Tottenham will play for all or nothing here and probably will win this key game and take advantage against Arsenal in this race for 4th place.